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- Title
Interactions between vitamin D and IGF-I: from physiology to clinical practice.
- Authors
Ameri, Pietro; Giusti, Andrea; Boschetti, Mara; Murialdo, Giovanni; Minuto, Francesco; Ferone, Diego
- Abstract
The interplay between vitamin D and IGF-I is complex and occurs at both endocrine and paracrine/autocrine levels. Vitamin D has been shown to increase circulating IGF-I and IGFBP-3, with the consistent finding of a positive correlation between vitamin D and IGF- I serum values in population-based cohorts of healthy subjects. The modulation of IGF- I and IGFBP-3 concentrations by vitamin D may impact recombinant human (rh) GH dosing for the treatment of GHD. It might also underlie some of the extra-skeletal beneficial effects ascribed to vitamin D. On the other hand, IGF-I stimulates renal production of 1,25-dihydroxyvitamin D, which increases calcium and phosphate availability in the body and suppresses PTH secretion. This effect is responsible for an altered calcium-phosphate balance in uncontrolled acromegaly and might also account for the improvement in bone metabolism associated with rh GH treatment in patients with GHD. Data on the paracrine/autocrine vitamin D− IGF-I interactions are abundant, but mostly not linked to one another. As a result, it is not possible to draw a comprehensive picture of the physiological and/or pathological interrelations between vitamin D, IGF- I and IGF-binding proteins ( IGFBP) in different tissues. A potential role of vitamin D action is related to its association with carcinogenesis, a paradigm being breast cancer. Current evidence indicates that, in breast tumours, vitamin D modulates the IGF-I/ IGFBP ratio to decrease proliferation and increase apoptosis.
- Subjects
VITAMIN D; SOMATOMEDIN C; AUTOCRINE mechanisms; ENDOCRINE glands; RECOMBINANT human somatotropin; PARATHYROID hormone-related protein
- Publication
Clinical Endocrinology, 2013, Vol 79, Issue 4, p457
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/cen.12268