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- Title
Soluble c-Met in serum of patients with multiple myeloma: correlation with clinical parameters.
- Authors
Wader, Karin F.; Fagerli, Unn-Merete; Holt, Randi U.; Børset, Magne; Sundan, Anders; Waage, Anders
- Abstract
Objectives: The receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor (HGF), play key roles in tumour genesis and metastasis and contribute in multiple myeloma pathogenesis. Substantial data support that a soluble extracellular fragment of c-Met may function as a decoy receptor that downregulates the biological effects of HGF and c-Met. We examined serum levels of soluble c-Met in patients with myeloma and healthy individuals and investigated a possible relationship with clinical disease parameters and survival. Methods: The concentration of c-Met and HGF was measured by enzyme-linked immunosorbent assay in serum ( n = 49) and bone marrow plasma ( n = 16) from patients with multiple myeloma and in serum from healthy controls ( n = 26). Results: The median serum concentration of soluble c-Met was 186 ng/mL (range 22-562) in patients with multiple myeloma and 189 ng/mL (range 124-397) in healthy individuals. There was a significant negative correlation between serum c-Met levels and disease stage, bone marrow plasma cell percentage and serum concentration of M-protein. Conclusion: We have for the first time examined the concentration of soluble c-Met in serum from patients with myeloma and found equal median levels in patients with myeloma as a group and healthy individuals. Still, serum levels of soluble c-Met correlated negatively with parameters of disease burden in patients with myeloma. We suggest that a possible role for the c-Met ectodomain as a negative regulator of HGF/c-Met activity should be examined in multiple myeloma.
- Subjects
MULTIPLE myeloma; HEPATOCYTE growth factor; SERUM; TYROSINE; BONE marrow
- Publication
European Journal of Haematology, 2011, Vol 87, Issue 5, p394
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/j.1600-0609.2011.01622.x