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- Title
Functional 5-HT1a receptor polymorphism selectively modulates error-specific subprocesses of performance monitoring.
- Authors
Beste, Christian; Domschke, Katharina; Kolev, Vasil; Yordanova, Juliana; Baffa, Anna; Falkenstein, Michael; Konrad, Carsten
- Abstract
Our study investigates the dependence of response monitoring and error detection on genetic influences modulating the serotonergic system. This was done using the event-related potentials (ERPs) after error (Ne/ERN) and correct trials (Nc/CRN). To induce a sufficient amount of errors, a standard flanker task was used. The subjects ( N = 94) were genotyped for the functional 5-HT1A C(−1019)G polymorphism. The results show that the 5-HT1A C(−1019)G polymorphism specifically modulates error detection. Neurophysiological modulations on error detection were paralleled by a similar modulation of response slowing after an error, reflecting the behavioral adaptation. The 5-HT1A −1019 CC genotype group showed a larger Ne and stronger posterror slowing than the CG and GG genotype groups. More general processes of performance monitoring, as reflected in the Nc/CRN, were not affected. The finding that error-specific processes, but not general response monitoring processes, are modulated by the 5-HT1A C(−1019)G polymorphism is underlined by a wavelet analysis. In summary, the results suggest a specific effect of the 5-HT1A C(−1019)G polymorphism on error monitoring, as reflected in the Ne, and suggest a neurobiological dissociation between processes of error monitoring and general response monitoring at the level of the serotonin 1A receptor system. Hum Brain Mapp, 2010. © 2009 Wiley-Liss, Inc.
- Publication
Human Brain Mapping, 2010, Vol 31, Issue 4, p621
- ISSN
1065-9471
- Publication type
Article
- DOI
10.1002/hbm.20892