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- Title
Riesgo de mortalidad asociado a enfermedad renal crónica en pacientes con diabetes tipo 2 durante un seguimiento de 13 años.
- Authors
Antonio Gimeno-Ornaa, José; Blasco-Lamarca, Yolanda; Campos-Gutierrez, Belén; Molinero-Herguedas, Edmundo; Miguel Lou-Arnal, Luis; García-García, Blanca
- Abstract
Objective: Our aimwas to assess the usefulness of glomerular filtration rate (GFR) and urinary albumin excretion (UAE) to predict the risk of mortality in patients with type 2 diabetes mellitus. Material and methods: This is a prospective cohort study in patients with type 2 diabetes mellitus. Clinical end-point was mortality rate. GFR was measured in ml/min/1.73 m2 and stratified in 3 categories (≥60; 45-59; <45); UAE was measured in mg/24 hours and was also stratified in 3 categories (<30; 30-300; >300). Mortality rates were reported per 1000 patientyears. Cox regression models were used to predict mortality risk associated with combined GFR and UAE. The predictive power was estimated with C-Harrell statistic. Results: A total of 453 patients (39.3% males), aged 64.9 (SD 9.3) years were included; mean diabetes duration was 10.4 (SD 7.5) years. Median follow-up was 13 years. Total mortality rate was 39.5/1000. The progressive increase in mortality in the successive categories of GFR and UAE was statistically significant (P<.001). In a multivariable analysis, UAE (HR30- 300 = 1.02 and HR> 300 = 2.83; X2 = 11.6; P =.003) and GFR (HR45-59 = 1.34 and HR< 45=1.84; X2 = 6.4; P =.041) were independent predictors for mortality, with no significant interaction. Simultaneous inclusion of GFR and UAE improved the predictive power of models (C-Harrell 0.741 vs. 0.726; P =.045). Conclusions: GFR and UAE are independent predictors for mortality in type 2 diabetic patients and do not show a statistically significant interaction.
- Publication
Nefrologia, 2015, Vol 35, Issue 5, p487
- ISSN
0211-6995
- Publication type
Article
- DOI
10.1016/j.nefro.2015.05.025