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- Title
Severe Group A Streptococcal Soft-Tissue Infections in Ontario: 1992-1996.
- Authors
Sharkawy, Abdu; Low, Donald E.; Saginur, Raphael; Gregson, Daniel; Schwartz, Benjamin; Jessamine, Peter; Green, Karen; McGeer, Allison
- Abstract
A prospective, population-based, surveillance study of invasive soft-tissue infections due to group Astreptococci was conducted in Ontario, Canada, from 1992 through 1996. Demographic and clinical information was obtained by patient interview and chart review. Isolates were characterized by M protein and T agglutination typing. The incidence of necrotizing fasciitis (NF) increased from 0.08 cases per 100,000 population in 1992 to 0.49 cases per 100,000 population in 1995. The case-fatality rate was 13% (68 of 520 patients died). Hypotension and multiorgan dysfunction complicated 64 cases (12%), and NF complicated 119 cases (23%). Underlying diabetes, alcohol abuse, cancer, and cardiac and pulmonary disease increased the risk of disease. Prior use of nonsteroidal anti-inflammatory agents did not influence disease severity. All 197 patients without NF, underlying illness, and hypotension at presentation survived, as did 95 (99%) of 96 normotensive patients who were <65 years old but who had underlying chronic illness. Previously healthy patients without hypo-tension or NF may be considered for outpatient treatment.
- Subjects
TISSUES; STREPTOCOCCAL diseases; NECROTIZING fasciitis; DISEASES
- Publication
Clinical Infectious Diseases, 2002, Vol 34, Issue 4, p454
- ISSN
1058-4838
- Publication type
Article