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- Title
A Trial Of A Group A Plus Group C Meningococcal Polysaccharide-Protein.
- Authors
Twumasi, Patrick A.; Kumah, Samuel; Leach, Amanda; O'Dempsey, Timothy J. D.; Ceesay, Serign J.; Todd, James; Broome, Claire V.; Carlone, George M.; Pais, Lorna B.; Holder, Patricia K.; Plikaytis, Brian D.; Greenwood, Brian M.
- Abstract
The safety and immunogenicity of a group A plus group C meningococcal polysaccharide CRM197 conjugate vaccine was evaluated in 304 8- to 10-week-old Gambian infants. Infants were immunized with one, two, or three doses of conjugate vaccine or with two doses of a meningococcal A plus C polysaccharide vaccine. The conjugate vaccine produced few systemic side effects, and local reactions were similar to those produced by the polysaccharide vaccine. Postvaccination group A meningococcal polysaccharide antibody levels, measured by ELISA, increased progressively after one, two, or three doses of conjugate vaccine. However, one dose of conjugate vaccine given at the age of 6 months induced a higher group C meningococcal antibody response than did two doses of conjugate vaccine given at 2 and 6 months. Two doses of conjugate vaccine induced higher levels of antibody than did two doses of polysaccharide vaccine. Thus, this new meningococcal conjugate vaccine proved to be safe and immunogenic.
- Publication
Journal of Infectious Diseases, 1995, Vol 171, Issue 3, p632
- ISSN
0022-1899
- Publication type
Article