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- Title
Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.
- Authors
Saraf, Santosh L.; Zhang, Xu; Shah, Binal N.; Raslan, Rasha; Tayo, Bamidele O.; Lash, James P.; Franceschini, Nora; Gordeuk, Victor R.
- Abstract
Sickle cell disease (SCD) and apolipoprotein L1 (APOL1) G1/G2 variants increase chronic kidney disease (CKD) risk in African Americans by poorly understood mechanisms. We applied bioinformatics to identify new candidate genes associated with SCD‐related CKD. An interaction network demonstrated APOA1 connecting haemoglobin subunit β (HBB) and APOL1 with 36 other candidate genes. Gene expression revealed upregulation of engulfment and cell motility 1 (ELMO1) and downregulation of APOA1 in the kidney cortex of SCD versus non‐SCD mice. Analysis of candidate genes identified ELMO1 rs10951509 to be associated with albuminuria and APOA1 rs11216132 with haemoglobinuria in patients with SCD. A bioinformatic approach highlights ELMO1 and APOA1 as potentially associated with SCD nephropathy.
- Subjects
CELL motility; SICKLE cell anemia; KIDNEY cortex; KIDNEY diseases; CHRONIC kidney failure
- Publication
British Journal of Haematology, 2021, Vol 193, Issue 3, p628
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.17224