We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of Intranasal Administration of CV-11974, a Type 1 Angiotensin II Receptor Antagonist, on Airway Hyperresponsiveness and Airway Inflammation Induced by Antigen Inhalation in Guinea Pigs.
- Authors
Myou, Shigeharu; Fujimura, Masaki; Kita, Toshiyuki; Watanabe, Kazuyoshi; Hirose, Tatsuki; Tachibana, Hideki; Ishiura, Yoshihisa; Nakao, Shinji
- Abstract
Background: Angiotensin II is a putative mediator in asthma, but the effect of topical administration of type 1 angiotensin II (AT1) receptor antagonists on allergic airway reactions is not known. Objective: To investigate the effect of intranasal administration of CV-11974, an AT1 receptor antagonist, and of PD123319, a type 2 angiotensin II (AT2) receptor antagonist, on antigen-induced airway reactions in guinea pigs. Methods: Thirty minutes after intranasal topical administration of CV-11974 (0.1 or 1.0 mg/ml) or PD123319 (10 mg/ml) into the airways, the animals were given an antigen challenge. Airway hyperresponsiveness and bronchoalveolar lavage fluid were analyzed 24 h after the antigen challenge. Results: Although these compounds did not inhibit antigen-induced early-phase bronchoconstriction or late-phase airway eosinophilia, intranasal administration of CV-11974 (but not PD123319) inhibited antigen-induced airway hyperresponsiveness in a dose-dependent manner 24 h after the antigen challenge. Conclusion: Intranasal administration of an AT1 receptor antagonist reduces antigen-induced airway hyperresponsiveness.Copyright © 2002 S. Karger AG, Basel
- Subjects
ANGIOTENSIN II; ANGIOTENSIN-receptor blockers; ALLERGIES; GUINEA pigs; EOSINOPHILS; PHYSIOLOGY
- Publication
International Archives of Allergy & Immunology, 2002, Vol 129, Issue 1, p86
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000065177