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- Title
The −202 A Allele of Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Promoter Polymorphism Is Associated with Higher IGFBP-3 Serum Levels and Better Growth Response to Growth Hormone Treatment in Patients with Severe Growth Hormone Deficiency.
- Authors
Costalonga, Everlayny Fiorot; Antonini, Sonir R.; Guerra-Junior, Gil; Bilharinho Mendonca, Berenice; Arnhold, Ivo J. P.; Jorge, Alexander A. L.
- Abstract
Context: Genetic factors that influence the response to recombinant human GH (rhGH) therapy remain mostly unknown. To date, only the GH receptor gene has been investigated. Objective: The aim of the study was to assess the influence of a polymorphism in the IGF-binding protein-3 (IGFBP-3) promoter region (−202 A/C) on circulating IGFBP-3 levels and growth response to rhGH therapy in children with GH deficiency (GHD). Design and Patients: −202 A/C IGFBP3 genotyping (rs2854744) was correlated with data of 71 children with severe GHD who remained prepubertal during the first year of rhGH treatment. Main Outcome Measures: We measured IGFBP-3 levels and first year growth velocity (GV) during rhGH treatment. Results: Clinical and laboratory data at the start of treatment were indistinguishable among patients with different −202 A/C IGFBP3 genotypes. Despite similar rhGH doses, patients homozygous for the A allele presented higher IGFBP-3 SD score levels and higher mean GV in the first year of rhGH treatment than patients with AC or CC genotypes (first year GV, AA = 13.0 ± 2.1 cm/yr, AC = 11.4 ± 2.5 cm/yr, and CC = 10.8 ± 1.9 cm/yr; P = 0.016). Multiple linear regression analyses demonstrated that the influence of −202 A/C IGFBP3 genotype on IGFBP-3 levels and GV during the first year of rhGH treatment was independent of other variables. Conclusion: The −202 A allele of IGFBP3 promoter region is associated with increased IGFBP-3 levels and GV during rhGH treatment in prepubertal GHD children.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2009, Vol 94, Issue 2, p588
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jc.2008-1608