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- Title
Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome.
- Authors
Wachs, Deborah S; Coffler, Mickey S; Malcom, Pamela J; Shimasaki, Shunichi; Chang, R Jeffrey
- Abstract
<bold>Context: </bold>In women with polycystic ovary syndrome (PCOS), excess ovarian androgen production is driven by increased LH secretion. Studies conducted in animals suggest that the granulosa cell may influence LH-stimulated theca cell androgen production.<bold>Objective: </bold>The objective of this study was to determine whether FSH enhances androgen production in women with PCOS compared with that of normal women.<bold>Design: </bold>A prospective study was conducted to compare androgen production in response to FSH in two groups of women.<bold>Setting: </bold>The study was conducted in a General Clinical Research Center in a tertiary academic medical center.<bold>Patients: </bold>Women with PCOS, 18-35 yr (n = 20), and normal ovulatory controls, 18-35 yr (n = 10), were recruited for study.<bold>Interventions: </bold>Serial blood samples were obtained over a 24-h period after an iv injection of recombinant human FSH (150 IU).<bold>Main Outcome Measures: </bold>The main outcome measures were serum 17-hydroxyprogesterone (17-OHP), androstenedione (A), dehydroepiandrosterone (DHEA), testosterone (T), and inhibin B (Inh B) responses after FSH administration.<bold>Results: </bold>Basal serum 17-OHP, A, and T levels were markedly increased in women with PCOS compared with that observed in normal women. Basal DHEA and Inh B levels were similar to those of normal controls. After FSH injection, PCOS women demonstrated enhanced production of 17-OHP, A, DHEA, and Inh B, whereas in normal women no increases were observed. T levels declined slightly in both groups.<bold>Conclusions: </bold>These findings provide evidence that, in PCOS women, theca cell androgen production is enhanced by FSH administration and suggest a granulosa-theca cell paracrine mechanism.
- Subjects
ANDROGENS; DEHYDROEPIANDROSTERONE; ESTRADIOL; FOLLICLE-stimulating hormone; GLYCOPROTEINS; HYDROCORTISONE; LONGITUDINAL method; LUTEINIZING hormone; PROGESTERONE; RESEARCH funding; POLYCYSTIC ovary syndrome; TESTOSTERONE; ANDROSTENEDIONE
- Publication
Journal of Clinical Endocrinology & Metabolism, 2008, Vol 93, Issue 5, p1827
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2007-2664