We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly associates to HLA-DRB15.
- Authors
Martinez-Martinez, Laura; Boera-Carnicero, Gemma; de la Calle Martin, Oscar; Juárez, Cándido; Pardo, Julio; Attarian, Shahram; Benedetti, Luana; Lauria, Guiseppe; Lleixà, Ma. Cinta; Siles, Ana; Diaz-Manera, Jordi; Illa, Isabel; Querol, Luis; Marchioni, Enrico; Franciotta, Diego; Callegari, Ilaria; Cortese, Andrea; Devaux, Jérôme; Delmont, Emilien; Rajabally, Yusuf
- Abstract
<bold>Background: </bold>The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies.<bold>Methods: </bold>Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients were included in a case-control study. The frequencies of the DRB1 HLA allele were analyzed in all patients while DQ frequencies were only studied in patients sharing the DRB1*15 allele. In silico HLA-peptide binding and NF155 antigenicity, predictions were performed to analyze overlap between presented peptides and antigenic regions.<bold>Results: </bold>DRB1*15 alleles (DRB1*15:01 and DRB1*15:02) were present in 10 out of 13 anti-NF155+ CIDP patients and in only 5 out of 35 anti-NF155neg CIDP patients (77 vs 14%; OR = 20, CI = 4.035 to 99.13). DRB1*15 alleles appeared also in significantly higher proportions in anti-NF155+ CIDP than in normal population (77 vs 17%; OR = 16.9, CI = 4.434 to 57.30). Seven anti-NF155+ CIDP patients (53%) and 5 anti-NF155neg CIDP patients had the DRB1*15:01 allele (OR = 7, p = 0.009), while 3 anti-NF155+ CIDP patients and none of the anti-NF155neg CIDP patients had the DRB1*15:02 allele (OR = 23.6, p = 0.016). In silico analysis of the NF155 peptides binding to DRB1*15 alleles showed significant overlap in the peptides presented by the 15:01 and 15:02 alleles, suggesting functional homology.<bold>Conclusions: </bold>DRB1*15 alleles are the first strong risk factor associated to a CIDP subset, providing additional evidence that anti-NF155+ CIDP patients constitute a differentiated disease within the CIDP syndrome.
- Subjects
HLA histocompatibility antigens; IMMUNOGLOBULINS; PEPTIDES; ALLELES; SYNDROMES; ANTIGENS; AUTOANTIBODIES; CELL adhesion molecules; DISEASE susceptibility; GENES; NERVE growth factor; GUILLAIN-Barre syndrome; HLA-B27 antigen; CASE-control method; GENOTYPES
- Publication
Journal of Neuroinflammation, 2017, Vol 14, p1
- ISSN
1742-2094
- Publication type
journal article
- DOI
10.1186/s12974-017-0996-1