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- Title
Interleukin-6: an emerging regulator of pathological pain.
- Authors
Ya-Qun Zhou; Zheng Liu; Zhi-Heng Liu; Shu-Ping Chen; Man Li; Shahveranov, Allahverdi; Da-Wei Ye; Yu-Ke Tian; Zhou, Ya-Qun; Liu, Zheng; Liu, Zhi-Heng; Chen, Shu-Ping; Li, Man; Ye, Da-Wei; Tian, Yu-Ke
- Abstract
Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and its receptor in the spinal cord and dorsal root ganglia. Additionally, the administration of interleukin-6 could cause mechanical allodynia and thermal hyperalgesia, and an intrathecal injection of anti-interleukin-6 neutralizing antibody alleviated these pain-related behaviors. These studies indicated a pivotal role of interleukin-6 in pathological pain. In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund's adjuvant injection, and carrageenan injection. Understanding and regulating interleukin-6 could be an interesting lead to novel therapeutic strategies for pathological pain.
- Subjects
INTERLEUKIN-6; PAIN management; ALLODYNIA; CANCER chemotherapy; CANCER pain; DORSAL root ganglia; THERAPEUTICS; ANIMALS; CELLULAR signal transduction; INTERLEUKINS; PAIN; PAIN measurement
- Publication
Journal of Neuroinflammation, 2016, Vol 13, p1
- ISSN
1742-2094
- Publication type
journal article
- DOI
10.1186/s12974-016-0607-6