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- Title
Characteristics of Faecal Microbiota in Korean Patients with Clostridioides difficile-associated Diarrhea.
- Authors
Yong Duk Jeon; Hea Won Ann; Woon Ji Lee; Jun Hyoung Kim; Hye Seong; Jung Ho Kim; Jin Young Ahn; Su Jin Jeong; Nam Su Ku; Joon Sup Yeom; Dongeun Yong; Kyungwon Lee; Jun Yong Choi
- Abstract
Background: The intestinal microbiota plays an important role in the pathogenesis of Clostridioides difficile-associated diarrhea, and regional and racial characteristics influence the microbiome composition and diversity. We investigated the intestinal microbiome characteristics of patients with C. difficile colitis (CD+) compared to those of patients with colitis not due to C. difficile (CD-), patients with vancomycin-resistant enterococci (VRE) colonization, and healthy controls, in Korea. Materials and Methods : We collected stool samples from 24,18,11 and 13 subjects within CD+, CD-, VRE and healthy control groups, respectively. The microbial communities were evaluated by 454-pyrosequencing of bacterial 16s rRNA. Results: The species richness and microbial diversity were significantly lower in the CD+ group compared to those in healthy controls, but not compared to those in CD- and VRE groups. Phylum-level analysis showed that the proportion of Actinobacteria in the CD+ group was significantly lower than in the healthy control, but was unchanged compared to that in CDand VRE groups. At the genus level, compared to the healthy group, ±e CD+ group showed significantly lower proportions of Blautia, Bifidobacterium, Faecalibacterium et al. Compared to the VRE group, the CD+ group showed a significantly higher proportion of Anaerostipes. Conclusions: We could identify the intestinal microbiome characteristics ofKoreans with C. difficile colitis. It might help to develop microbiome based diagnostic and treatment modalities.
- Subjects
SOUTH Korea; GUT microbiome; DIARRHEA; MICROBIAL diversity; PATHOLOGY; SPECIES diversity
- Publication
Infection & Chemotherapy, 2019, Vol 51, Issue 4, p365
- ISSN
2093-2340
- Publication type
Article
- DOI
10.3947/ic.2019.51.4.365