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- Title
Interference-free determination of ultra-trace concentrations of arsenic and selenium using methyl fluoride as a reaction gas in ICP-MS/MS.
- Authors
Bolea-Fernandez, Eduardo; Balcaen, Lieve; Resano, Martín; Vanhaecke, Frank
- Abstract
Interference-free conditions, allowing straightforward As and Se determination, can be obtained by using CHF (a mixture of 10 % CHF and 90 % He) as a reaction gas in tandem ICP-mass spectrometry (ICP-MS/MS). Both target elements react via CHF addition and subsequent HF elimination, rendering AsCH and SeCH the respective favored reaction product ions. Instrumental limits of detection were 0.2 ng L for As and below 10 ng L for Se, using either Se, Se, or Se. Neither addition of carbon to the solutions, nor admixing of additional He into the octopole reaction cell resulted in a further improvement of the LoDs, despite the increase in analyte signal intensity. By using synthetic matrices, containing elements giving rise to ions interfering at either the original mass-to-charge ratios or those of the reaction products, absence of spectral overlap could be demonstrated. This conclusion was corroborated by successful As and Se determination in a collection of reference materials from plant, animal, or environmental origin, displaying a considerable range of As and Se contents. These accurate results were obtained via external calibration using Te as an internal standard. The high efficiency reaction between As and CHF and the possibility to use the major isotope of Se provides enhanced detection power versus other techniques, such as sector-field ICP-mass spectrometry, while the possibility to monitor at least three Se isotopes interference-free also enables isotopic analysis. [Figure not available: see fulltext.]
- Subjects
ARSENIC; SELENIUM; MASS spectrometry; MATRICES (Mathematics); ISOTOPES
- Publication
Analytical & Bioanalytical Chemistry, 2015, Vol 407, Issue 3, p919
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-014-8195-8