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- Title
Multi‐modal functional MRI to explore placental function over gestation.
- Authors
Hutter, Jana; Slator, Paddy J.; Jackson, Laurence; Gomes, Ana Dos Santos; Ho, Alison; Story, Lisa; O'Muircheartaigh, Jonathan; Teixeira, Rui P. A. G.; Chappell, Lucy C.; Alexander, Daniel C.; Rutherford, Mary A.; Hajnal, Joseph V.
- Abstract
Purpose: To investigate, visualize and quantify the physiology of the human placenta in several dimensions ‐ functional, temporal over gestation, and spatial over the whole organ. Methods: Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi‐modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre‐eclampsia. Results: A multi‐faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation. Conclusions: The obtained multi‐modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.
- Publication
Magnetic Resonance in Medicine, 2019, Vol 81, Issue 2, p1191
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.27447