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- Title
Combined Expression of HLA-DR Antigen and Proliferating Cell Nuclear Antigen Correlate with Colorectal Cancer Prognosis.
- Authors
Kunihiro, Masaki; Tanaka, Shinji; Haruma, Ken; Yoshihara, Masaharu; Sumii, Koji; Kajiyama, Goro; Shimamoto, Fumio
- Abstract
HLA-DR antigen expression and the proliferating cell nuclear antigen labeling index (PCNA-LI) were examined immmunohistochemically in 59 surgically resected advanced colorectal cancers to clarify the clinicopathologic significance of the HLA-DR antigen. HLA-DR antigen expression was detected in 33 (56%) of the 59 lesions, which showed less frequent liver metastasis than lesions without HLA-DR antigen expression (40 vs. 68%; p < 0.05). Five-year survival rates of patients with and without HLA-DR antigen expression were 50 and 19%, respectively. Lesions combining HLA-DR antigen expression and a relatively low PCNA-LI had the best prognosis. These results indicate that HLA-DR antigen expression, particularly combined with a low PCNA-LI, is an important outcome predictor in colorectal cancer.
- Subjects
GENE expression; ANTIGENS; CELL proliferation; CANCER diagnosis; COLON cancer; PROGNOSIS
- Publication
Oncology, 1998, Vol 55, Issue 4, p326
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000011870