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- Title
Xanthones from the Fermentation Products of the Endophytic Fungus of Phomopsis amygdali.
- Authors
Hu, Qiufen; Yang, Yuchun; Yang, Shuai; Cao, Hongyun; Chunyang, Meng; Yang, Haiyin; Gao, Xuemei; Du, Gang
- Abstract
Two new xanthones, 3-methoxy-1,4,8-trihydroxy-5-(1′,3′,4′-trihydroxybutan-2′-yl)-xanthone ( 1), 8-methoxy-1,3,4-trihydroxy-5-(1′,3′,4′-trihydroxybutan-2′-yl)-xanthone ( 2), and three known xanthones ( 3-5) were isolated from the fermentation products of a Phomopsis fungus. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-5 were tested for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7). Compound 1 showed cytotoxicity against A549 with IC values of 3.6 μM. Compound 2 showed cytotoxicity against SHSY5Y cells with IC value of 4.2 μM. The other compounds also showed potential cytotoxicity for some tested cell lines with IC50 values between 5.4-8.8 μM.
- Subjects
FERMENTATION; METHOXY compounds; SPECTRUM analysis; PHOMOPSIS; PHOMOPSIS diseases
- Publication
Chemistry of Natural Compounds, 2015, Vol 51, Issue 3, p456
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-015-1314-8