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- Title
Complex versus simple models: ion-channel cardiac toxicity prediction.
- Authors
Mistry, Hitesh B.
- Abstract
There is growing interest in applying detailed mathematical models of the heart for ion-channel related cardiac toxicity prediction. However, a debate as to whether such complex models are required exists. Here an assessment in the predictive performance between two established large-scale biophysical cardiac models and a simple linear model Bnet was conducted. Three ion-channel data-sets were extracted from literature. Each compound was designated a cardiac risk category using two different classification schemes based on information within CredibleMeds. The predictive performance of each model within each data-set for each classification scheme was assessed via a leaveone- out cross validation. Overall the Bnet model performed equally as well as the leading cardiac models in two of the data-sets and outperformed both cardiac models on the latest. These results highlight the importance of benchmarking complex versus simple models but also encourage the development of simple models.
- Subjects
ION channels; HEART models; BIOPHYSICS; MATHEMATICAL models; PREDICTION theory
- Publication
PeerJ, 2018, p1
- ISSN
2167-8359
- Publication type
Article
- DOI
10.7717/peerj.4352