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- Title
Association Study Indicates a Protective Role of Phosphatidylinositol-4-Phosphate-5-Kinase against Tardive Dyskinesia.
- Authors
Fedorenko, Olga Yu; Loonen, Anton J. M.; Lang, Florian; Toshchakova, Valentina A.; Boyarko, Evgenia G.; Semke, Arkadiy V.; Bokhan, Nikolay A.; Govorin, Nikolay V.; Aftanas, Lyubomir I.; Ivanova, Svetlana A.
- Abstract
Background: Tardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as a complication of long-term treatment with antipsychotic drugs. It has been suggested to be related to a malfunctioning of the indirect pathway of the motor part of the cortical-striatal-thalamic-cortical circuit, which may be caused by oxidative stress-induced neurotoxicity. Methods: The purpose of our study was to investigate the possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive dyskinesia in 491 Caucasian patients with schizophrenia from 3 different psychiatric institutes in West Siberia. The Abnormal Involuntary Movement Scale was used to assess tardive dyskinesia. Individuals were genotyped for 3 single nucleotide polymorphisms in PIP5K2A gene: rs10828317, rs746203, and rs8341. Results: A significant association was established between the functional mutation N251S-polymorphism of the PIP5K2A gene (rs10828317) and tardive dyskinesia, while the other 2 examined nonfunctional single nucleotide polymorphisms were not related. Conclusions: We conclude from this association that PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. This corresponds to our hypothesis that tardive dyskinesia is related to neurotoxicity at striatal indirect pathway medium-sized spiny neurons.
- Subjects
TARDIVE dyskinesia; MOVEMENT disorders; MUSCLE diseases; PHOSPHATIDYLINOSITOL 3-kinases; ANTIPSYCHOTIC agents; MOTOR ability
- Publication
International Journal of Neuropsychopharmacology, 2015, Vol 18, Issue 6, p1
- ISSN
1461-1457
- Publication type
Article
- DOI
10.1093/ijnp/pyu098