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- Title
Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis.
- Authors
Esberg, Anders; Johansson, Linda; Berglin, Ewa; Mohammad, Aladdin J.; Jonsson, Andreas P.; Dahlqvist, Johanna; Stegmayr, Bernd; Johansson, Ingegerd; Rantapää-Dahlqvist, Solbritt
- Abstract
Microbiota has been associated with autoimmune diseases, with nasal Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV). Little is known about the role of oral microbiota in AAV. In this study, levels of IgG antibodies to 53 oral bacterial species/subspecies were screened using immunoblotting in plasma/serum in pre-symptomatic AAV-individuals (n = 85), matched controls, and established AAV-patients (n = 78). Saliva microbiota from acute-AAV and controls was sequenced from 16s rDNA amplicons. Information on dental status was extracted from a national register. IgG levels against oral bacteria were lower in established AAV versus pre-AAV and controls. Specifically, pre-AAV samples had, compared to controls, a higher abundance of periodontitis-associated species paralleling more signs of periodontitis in established AAV-patients than controls. Saliva microbiota in acute-AAV showed higher within-sample diversity but fewer detectable amplicon-sequence variants and taxa in their core microbiota than controls. Acute-AAV was not associated with increased abundance of periodontal bacteria but species in, e.g., Arthrospira, Staphylococcus, Lactobacillus, and Scardovia. In conclusion, the IgG profiles against oral bacteria differed between pre-AAV, established AAV, and controls, and microbiota profiles between acute AAV and controls. The IgG shift from a pre-symptomatic stage to established disease cooccurred with treatment of immunosuppression and/or antibiotics.
- Subjects
MUPIROCIN; VASCULITIS; THERAPEUTICS; MICROSCOPIC polyangiitis; GRANULOMATOSIS with polyangiitis; STAPHYLOCOCCUS aureus; NEUTROPHILS; IMMUNOGLOBULIN G
- Publication
Microorganisms, 2022, Vol 10, Issue 8, p1572
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms10081572