We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Antiparasitic Drugs against SARS-CoV-2: A Comprehensive Literature Survey.
- Authors
Calvo-Alvarez, Estefanía; Dolci, Maria; Perego, Federica; Signorini, Lucia; Parapini, Silvia; D'Alessandro, Sarah; Denti, Luca; Basilico, Nicoletta; Taramelli, Donatella; Ferrante, Pasquale; Delbue, Serena
- Abstract
More than two years have passed since the viral outbreak that led to the novel infectious respiratory disease COVID-19, caused by the SARS-CoV-2 coronavirus. Since then, the urgency for effective treatments resulted in unprecedented efforts to develop new vaccines and to accelerate the drug discovery pipeline, mainly through the repurposing of well-known compounds with broad antiviral effects. In particular, antiparasitic drugs historically used against human infections due to protozoa or helminth parasites have entered the main stage as a miracle cure in the fight against SARS-CoV-2. Despite having demonstrated promising anti-SARS-CoV-2 activities in vitro, conflicting results have made their translation into clinical practice more difficult than expected. Since many studies involving antiparasitic drugs are currently under investigation, the window of opportunity might be not closed yet. Here, we will review the (controversial) journey of these old antiparasitic drugs to combat the human infection caused by the novel coronavirus SARS-CoV-2.
- Subjects
ANTIPARASITIC agents; CORONAVIRUSES; SARS-CoV-2; RESPIRATORY diseases; COVID-19; VACCINE development; DRUG discovery
- Publication
Microorganisms, 2022, Vol 10, Issue 7, pN.PAG
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms10071284