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- Title
Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality.
- Authors
Dafinger, Claudia; Benzing, Thomas; Dötsch, Jörg; Schermer, Bernhard; Liebau, Max C.
- Abstract
Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first description linking the AAA+ (ATPases associated with various cellular activities) superfamily protein Ruvbl1 to mammalian epidermal development. Keratinocyte-specific Ruvbl1 knockout mice (Ruvbl1fl/flK14:Cretg) show a severe phenotype including dramatic structural epidermal defects resulting in the loss of the functional skin barrier and perinatal death. Thus, Ruvbl1 is a newly identified essential player for the development of differentiated epidermis in mice.
- Subjects
PERINATAL death; CELL communication; KNOCKOUT mice; CELL proliferation; CELL death; KERATINOCYTE differentiation
- Publication
Molecular & Cellular Pediatrics, 2021, Vol 8, Issue 1, p1
- ISSN
2194-7791
- Publication type
Article
- DOI
10.1186/s40348-021-00111-1