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- Title
Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson's Disease: The Emerging Role of VDAC.
- Authors
Risiglione, Pierpaolo; Zinghirino, Federica; Di Rosa, Maria Carmela; Magrì, Andrea; Messina, Angela; Uversky, Vladimir N.
- Abstract
Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various substrates towards the organelle. Furthermore, they act as a mitochondrial hub for many cytosolic proteins, including αSyn. This review analyzes the main aspects of αSyn-mitochondria interaction, focusing on the role of VDAC and its emerging involvement in the pathological processes.
- Subjects
PARKINSON'S disease; ALPHA-synuclein; MITOCHONDRIA
- Publication
Biomolecules (2218-273X), 2021, Vol 11, Issue 5, p718
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom11050718