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- Title
EndoBarrier™ Implantation Rapidly Improves Insulin Sensitivity in Obese Individuals with Type 2 Diabetes Mellitus.
- Authors
Obermayer, Anna; Tripolt, Norbert J.; Aziz, Faisal; Högenauer, Christoph; Aberer, Felix; Schreiber, Florian; Eherer, Andreas; Sourij, Caren; Stadlbauer, Vanessa; Svehlikova, Eva; Brunner, Martina; Goswami, Nandu; Kojzar, Harald; Pferschy, Peter N.; Pieber, Thomas R.; Sourij, Harald
- Abstract
The EndoBarrier™ medical device is a duodenal-jejunal bypass liner designed to mimic the effects of gastric bypass surgery to induce weight loss and glycaemic improvement. In this study, 10 participants with type 2 diabetes mellitus (T2DM), a mean body mass index (BMI) of 43.3 ± 5.0 (kg/m2) and a mean glycated haemoglobin A1c (HbA1c) of 60.6 ± 8.6 mmol/mol were examined at baseline (before implantation of EndoBarrier™), 4 weeks after implantation, at 36 weeks (right before explantation) and 24 weeks after the removal of the device to explore the short and long-term effects on glucose metabolism. Besides a significant reduction in body weight and fat mass, EndoBarrier™ treatment significantly improved insulin sensitivity during Botnia clamp investigations after four weeks of implantation. The beneficial effects decreased over time but remained significant 24 weeks after removal of the device.
- Subjects
TYPE 2 diabetes; INSULIN sensitivity; GLYCOSYLATED hemoglobin; WEIGHT loss; ADIPOSE tissues; GASTRIC bypass; UMBILICAL cord clamping
- Publication
Biomolecules (2218-273X), 2021, Vol 11, Issue 4, p574
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom11040574