We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
INTRAVENOUS IRON TREATMENT IN PATIENTS WITH CHRONIC RENAL DİSEASE, OXIDATIVE STRESS AND THE EFFECT OF N- ACETYL CYSTEINE.
- Authors
SAKĠN, Y. Serdar; KARAMAN, Murat; AY, Ahmet; AKAY, Cemal; ÇAKIR, Erdinç; AÇIKEL, Cengizhan; ÜNAL, Hilmi Umut; EKEN, Ayşe; SAĞLAM, Kenan; ÇAĞLAR, Kayser; OGUZ, Yusuf
- Abstract
OBJECTIVE One of the problems in treating anemia of CRD is iron deficiency and intravenous (IV) iron supplementation has become an accepted therapy of iron deficiency in CRD patients. But, it is known that free iron is prooxidant and causes oxidative stress by generation of hydroxyl radicals through the fenton reaction. The purpose of this study is to determine the relationship between IV iron treatment and oxidative stress, and to determine the effect of N-acetyl cysteine (NAC), which is an antioxidant, on this possible oxidative stress. MATERIAL AND METHOD The 30 patients with iron deficiency anemia and CRD (stage3-5 according to K/DOQI)by whom planned to be given IV iron treatment, separated to two groups. One group took only IV iron, and the other group took NAC orally beside IV iron treatment. In each group, Malondialdehyde (MDA), glutathione peroxidase (GPx), catalase(CAT) and superoxide dismutase(SOD) levels were studied to determine oxidative stress. RESULTS In IV iron treatment group, antioxidant enzyme levels erythrocyte Glutathione peroxidase (GPx) and catalase (CAT) decreased significantly but erythrocyte superoxide dismutase (SOD) activity didn‟t change. With NAC pretreatment, decreasing of CAT levels prevented, but GPx levels decreased significantly. And also SOD levels did not change from the baseline. CONCLUSION: Our study shows that IV iron therapy in CRD changes some oxidative stress parameters. 600 mg/d NAC pre-treatment does not make antioxidant effect on IV iron therapy significantly.
- Publication
Balkan Military Medical Review, 2013, Vol 16, p199
- ISSN
1107-6275
- Publication type
Article