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- Title
SIK2 regulates insulin secretion.
- Authors
Belgardt, Bengt-Frederik; Stoffel, Markus
- Abstract
Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.
- Subjects
INSULIN; PANCREAS; KINASES; HOMEOSTASIS; INTRACELLULAR calcium
- Publication
Nature Cell Biology, 2014, Vol 16, Issue 3, p210
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb2925