We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Allogeneic stem cell transplantation for advanced acute promyelocytic leukemia: results in patients treated in second molecular remission or with molecularly persistent disease.
- Authors
Lo-Coco, F.; Romano, A.; Mengarelli, A.; Diverio, D.; Iori, A.P.; Moleti, M.L.; De Santis, S.; Carretti, R.; Mandelli, F.; Arcese, W.
- Abstract
In all, 17 consecutive patients in hematological complete remission (HCR) of acute promyelocytic leukemia (APL) received allogeneic stem cell transplantation (SCT) from an HLA-identical sibling and were monitored by reverse transcriptase polymerase chain reaction of PML/RARa prior and after transplant. Median age was 31 years (range 3-50 years). At 10 years, the actuarial probabilities of nonrelapse mortality, relapse and disease-free survival were 32% (95% CI: 8-56%), 33% (95% CI: 6-60%) and 46% (95% CI: 22-70%). Six patients tested PCR +ve (1st HCR n=2; 2nd HCR n=3; 3rd HCR n=1) and 11 PCR -ve (2nd HCR n=11) pre-SCT. Of the six patients PCR +ve, two showed early persistence of PCR positivity and converted to sustained PCR negativity after CSA withdrawal (one died of secondary tumor in molecular remission and one is alive in relapse), while four converted to PCR -ve rapidly (one died of the underlying disease and three are in molecular remission). Of the 11 patients PCR -ve pre-SCT, six died (four of transplant-related mortality, one of relapse and one after heart transplantation) and five are alive, four in molecular remission and one is in relapse. Allogeneic SCT seems a valid option for advanced APL, particularly for the poor prognostic group of patients with pre-SCT molecularly persistent disease.Leukemia (2003) 17, 1930-1933. doi:10.1038/sj.leu.2403078
- Subjects
STEM cells; CELL transplantation; MYELOID leukemia
- Publication
Leukemia (08876924), 2003, Vol 17, Issue 10, p1930
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/sj.leu.2403078