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- Title
Therapy-related adult acute lymphoblastic leukemia with t(4;11)(q21; q23): MLL rearrangement, p53 mutation and multilineage involvement.
- Authors
Bigoni, R; Cuneo, A; Roberti, M Grazia; Moretti, S; De Angeli, C; Dabusti, M; Campioni, D; Senno, L del; Biondi, A; Chaplin, T; Young, B D; Castoldi, G; Roberti, M G; del Senno, L
- Abstract
A diagnosis of pro-B acute lymphoblastic leukemia (ALL) with CD15+ was made in a 42-year-old woman, 12 months after the treatment of uterine adenocarcinoma by carboplatinum, anthracyclines, etoposide and radiotherapy. Molecular cytogenetic studies revealed a karyotype with multiple chromosome changes, including the t(4;11)(q21;q23) and a 17p-chromosome, with MLL disruption and 17p13/p53 gene deletion in 86% of the cells. A p53 exon 6 mutation was documented, resulting in p53 protein stabilization, with 20% of the cells reacting with the 1801 anti-p53 monoclonal antibody. Dual-color FISH using MLL and p53 probes was performed on peripheral blood smears, providing direct evidence of the involvement of the blast cells and of the granulocytic lineage. Only a partial, shortlasting response was obtained by induction treatment, confirming that a poor prognosis is associated with therapy-related ALL with the 4;11 translocation.
- Subjects
LYMPHOBLASTIC leukemia; ADENOCARCINOMA; CHROMOSOME abnormalities; CHROMOSOMES; COMPARATIVE studies; GENES; RESEARCH methodology; MEDICAL cooperation; GENETIC mutation; ONCOGENES; PROTEINS; RESEARCH; TRANSCRIPTION factors; TRANSFERASES; DNA-binding proteins; EVALUATION research; SECONDARY primary cancer
- Publication
Leukemia (08876924), 1999, Vol 13, Issue 5, p704
- ISSN
0887-6924
- Publication type
journal article
- DOI
10.1038/sj.leu.2401391