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- Title
Ascorbic acid deficiency aggravates stress-induced gastric mucosal lesions in genetically scorbutic ODS rats.
- Authors
Ohta, Y.; Chiba, S.; Imai, Y.; Kamiya, Y.; Arisawa, T.; Kitagawa, A.
- Abstract
We examined whether ascorbic acid (AA) deficiency aggravates water immersion restraint stress (WIRS)-induced gastric mucosal lesions in genetically scorbutic ODS rats. ODS rats received scorbutic diet with either distilled water containing AA (1 g/l) or distilled water for 2 weeks. AA-deficient rats had 12% of gastric mucosal AA content in AA-sufficient rats. AA-deficient rats showed more severe gastric mucosal lesions than AA-sufficient rats at 1, 3 or 6 h after the onset of WIRS, although AA-deficient rats had a slight decrease in gastric mucosal AA content, while AA-sufficient rats had a large decrease in that content. AA-deficient rats had more decreased gastric mucosal nonprotein SH and vitamin E contents and increased gastric mucosal lipid peroxide content than AA-sufficient rats at 1, 3 or 6 h of WIRS. These results indicate that AA deficiency aggravates WIRS-induced gastric mucosal lesions in ODS rats by enhancing oxidative damage in the gastric mucosa.
- Subjects
VITAMIN C deficiency; GASTRIC mucosa; WATER immersion; DISTILLED water; RATS
- Publication
Inflammopharmacology, 2006, Vol 14, Issue 5/6, p231
- ISSN
0925-4692
- Publication type
Article
- DOI
10.1007/s10787-006-1539-z