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- Title
Targeting LGR5<sup>+</sup> cells with an antibody-drug conjugate for the treatment of colon cancer.
- Authors
Junttila, Melissa R.; Weiguang Mao; Xi Wang; Bu-Er Wang; Thinh Pham; Flygare, John; Shang-Fan Yu; Sharon Yee; Goldenberg, David; Fields, Carter; Eastham-Anderson, Jeffrey; Singh, Mallika; Vij, Rajesh; Jo-Anne Hongo; Firestein, Ron; Schutten, Melissa; Flagella, Kelly; Polakis, Paul; Polson, Andrew G.
- Abstract
The article focuses on a research on targeting leucine-rich repeat–containing G protein–coupled receptor 5 (LGR5) cells with an antibody-drug conjugate for the treatment of colon cancer. It discusses potential of tumor efficacy and safety of one antibody-drug conjugate in vivo and decrease in tumor size and proliferation.
- Subjects
COLON cancer treatment; LEUCINE; G protein coupled receptors; ANTIBODY-drug conjugates; TUMOR growth
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 314, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aac7433