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- Title
Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.
- Authors
Cuende, Julia; Liénart, Stéphanie; Dedobbeleer, Olivier; van der Woning, Bas; De Boeck, Gitte; Stockis, Julie; Huygens, Caroline; Colau, Didier; Somja, Joan; Delvenne, Philippe; Hannon, Muriel; Baron, Frédéric; Dumoutier, Laure; Renauld, Jean-Christophe; De Haard, Hans; Saunders, Michael; Coulie, Pierre G.; Lucas, Sophie
- Abstract
The article focuses on findings of a study on effects of monoclonal antibodies against GARP/TGF-beta 1 complexes in inhibiting the immunosuppressive activity of human regulatory T cells. It states that two anti-GARP monoclonal antibodies were generated that block the production of the active TGF complexes, and mentions that antibodies recognizing other GARP epitopes did not block active TGF. It infers that blocking anti-GARP antibodies may improve the efficiency of cancer immunotherapy.
- Subjects
MONOCLONAL antibodies; TRANSFORMING growth factors-beta; IMMUNOSUPPRESSION; T cells; IMMUNOGLOBULINS; EPITOPES; CANCER immunotherapy; PHYSIOLOGY
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 284, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaa1983