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- Title
Effects of SR141716A on Cognitive and Depression-Related Behavior in an Animal Model of Premotor Parkinson's Disease.
- Authors
Tadaiesky, M. T.; Dombrowski, P. A.; Da Cunha, C.; Takahashi, R. N.
- Abstract
A previous study from our laboratory revealed that moderate nigral dopaminergic degeneration caused emotional and cognitive deficits in rats, paralleling early signs of Parkinson's disease. Recent evidence suggests that the blockade of cannabinoid CB1 receptors might be beneficial to alleviate motor inhibition typical of Parkinson's disease. Here, we investigated whether antagonism of CB1 receptors would improve emotional and cognitive deficits in a rat model of premotor Parkinson's disease. Depressionlike behavior and cognition were assessed with the forced swim test and the social recognition test, respectively. Confirming our previous study, rats injected with 6-hydroxydopamine in striatum presented emotional and cognitive alterations which were improved by acute injection of SR141716A. HPLC analysis of monoamine levels demonstrated alterations in the striatum and prefrontal cortex after SR141716A injection. These findings suggest a role for CB1 receptors in the early symptoms caused by degeneration of dopaminergic neurons in the striatum, as observed in Parkinson's disease.
- Subjects
PARKINSON'S disease; MENTAL depression; PREFRONTAL cortex; DOPAMINERGIC neurons; LABORATORY rats; CANNABINOIDS; MONOAMINE oxidase; DEGENERATION (Pathology)
- Publication
Parkinson's Disease (20420080), 2010, p1
- ISSN
2090-8083
- Publication type
Article
- DOI
10.4061/2010/238491