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- Title
Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis.
- Authors
ROSSBACH, Kristine; WAHLE, Katharina; BRUER, Gustav; BREHM, Ralph; LANGEHEINE, Marion; RODE, Kristina; SCHAPER-GERHARDT, Katrin; GUTZMER, Ralf; WERFEL, Thomas; KIETZMANN, Manfred; BÄUMER, Wolfgang
- Abstract
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch. Histamine, acting via histamine 1-4 receptors, is known to modulate immune responses in the skin and to induce itch. The aim of this study was to test the role of histamine 2 receptors and histamine 4 receptors in the imiquimod-induced psoriasis-like skin inflammation model. BALB/c mice were treated intraperitoneally with amthamine (histamine 2 receptor agonist), JNJ-39758979 (histamine 4 receptor antagonist), a combination of both, or vehicle twice daily in a preventive manner. Imiquimod was applied once daily onto the back skin for 10 consecutive days. Stimulation of histamine 2 receptors and blockade of histamine 4 receptors ameliorated imiquimod-induced skin inflammation. The combination of amthamine and JNJ-39758979 reduced skin inflammation even more, diminished epidermal hyperproliferation, and inhibited spontaneous scratching behaviour. A combination of histamine 2 receptor agonist and histamine 4 receptor antagonists could represent a new strategy for the treatment of psoriasis.
- Subjects
HISTAMINE receptors; ANTIHISTAMINES; PSORIASIS; SKIN inflammation; IMIQUIMOD
- Publication
Acta Dermato-Venereologica, 2020, Vol 100, Issue 12, p1
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-3674