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- Title
Correlation Between Parathyroid Hormone Levels with Urinary Magnesium Excretion in Patients with Non-Dialysis Dependent Chronic Kidney Disease.
- Authors
Dias, Raimunda Sheyla Carneiro; Brito, Dyego José de Araújo; Santos, Elisângela Milhomem dos; Costa, Rayanna Cadilhe de Oliveira; Fontenele, Andrea Martins Melo; Furtado, Elane Viana Hortegal; Lages, Joyce Santos; Santos, Alcione Miranda dos; Santos, Elton Jonh Freitas; Carneiro, Érika Cristina Ribeiro de Lima; Diniz, Maria Célia Cruz; Barbosa, Carla Déa Trindade; Muniz, Alessandra Costa de Sales; França, Ana Karina Teixeira da Cunha; Filho, Natalino Salgado; Araújo, Denizar Vianna; Bernardo-Filho, Mário
- Abstract
aimunda Sheyla Carneiro Dias,1 Dyego José de Araújo Brito,1 ElisÃngela Milhomem dos Santos,2 Rayanna Cadilhe de Oliveira Costa,1 Andrea Martins Melo Fontenele,1 Elane Viana Hortegal Furtado,1 Joyce Santos Lages,1 Alcione Miranda dos Santos,3 Elton Jonh Freitas Santos,1 Érika Cristina Ribeiro de Lima Carneiro,1 Maria Célia Cruz Diniz,1 Carla Déa Trindade Barbosa,1 Alessandra Costa de Sales Muniz,1 Ana Karina Teixeira da Cunha França,3 Natalino Salgado Filho,4 Denizar Vianna Araújo,5 Mário Bernardo-Filho61Center for Prevention of Kidney Diseases, University Hospital of the Federal University of Maranhão, São Luís, MA, Brazil; 2Nursing Department, Federal University of Maranhão, São Luís, MA, Brazil; 3Public Health Department, Federal University of Maranhão, São Luís, MA, Brazil; 4Department of Medicine I, Federal University of Maranhão, São Luís, MA, Brazil; 5Department of Internal Medicine, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; 6Laboratory of Mechanical Vibrations and Integrative Practices, Department of Biophysics and Biometrics, Institute of Biology Roberto AlcÃntara Gomes and Polyclinic Américo Piquet Carneiro, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, BrazilCorrespondence: Raimunda Sheyla Carneiro Dias Tel +55 98 981545296Email sheylak75@yahoo.com.br Background: Disorders of mineral metabolism occur in most patients with chronic kidney disease (CKD). The aim of this work was to correlate parathyroid hormone (PTH) levels with urinary magnesium excretion in patients with non-dialysis dependent CKD. Methods: Cross-sectional study. Concentrations of creatinine, magnesium, calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D] and alkaline phosphatase (ALP) were determined in blood samples. The assessment of urinary magnesium levels was performed by means of total daily excretion and by the excretion fraction (FEMg). Results: The study evaluated 163 patients with a mean age of 60.7 ± 11.7 years and 51.0% were male. In the highest quartile of PTH (> 89.5pg/mL), the mean levels of FEMg and ALP were higher (p< 0.05). In the unadjusted regression analysis, the following variables were related to serum PTH levels: FEMg (odds ratio (OR) = 1.12; 95% confidence intervals (CI): 1.02– 1.23), calcium (OR = 0.45; 95% CI: 0.22– 0.90), ALP (OR = 1.02; 95% CI: 1.00– 1.03) and eGFR (OR = 0.92; 95% CI: 1.00– 1.03). After an adjusted analysis, only one FEMg and ALP will remain correlated with PTH. Conclusion: In patients with non-dialysis dependent CKD, FEMg and ALP were some variables that remained associated with PTH.
- Subjects
SAO Luis do Maranhao (Brazil); BRAZIL; CHRONIC kidney failure; ERYTHROPOIETIN receptors; PARATHYROID hormone; MAGNESIUM; HEMODIALYSIS patients
- Publication
International Journal of Nephrology & Renovascular Disease, 2020, Vol 13, p341
- ISSN
1178-7058
- Publication type
Article
- DOI
10.2147/IJNRD.S282106