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- Title
Expression of serum fucosyltransferase 8 in oral squamous cell carcinoma and potentially malignant disorder - A case-control study.
- Authors
Rupa, Jesline; Ramani, Pratibha; Premkumar, Priya; Natesan, Anuja; Sherlin, Herald J.
- Abstract
Introduction: Oral squamous cell carcinoma is the sixth most common human malignancy that is highly lethal due to its recurrenceand metastasis. When fucose is attached by a fucosyltransferase enzyme through a glycosidic bond to a biomolecule, it becomes a fucosylated molecule. A universal hallmark of tumor cells is the change in their glycosylation phenotype, of which fucosylation is the more important oligosaccharide modification. Case Study: The study evaluates the levels of serum fucosyltransferase 8 (FUT 8) in oral squamous cell carcinoma patients, patients with potentially malignant disorders, namely, leukoplakia and oral submucous fibrosis (OSMF) and healthy controls. Results: The progressive increase in serum FUT 8 between healthy controls, patients with potentially malignant disorders, namely, leukoplakia and OSMF and oral squamous cell carcinoma patients, substantiates the crucial role of FUT 8 in malignant transformation, progression, metastasis, recurrence, and poor overall survival.
- Subjects
SQUAMOUS cell carcinoma; ORAL leukoplakia; ORAL submucous fibrosis; CASE-control method; SERUM
- Publication
Drug Invention Today, 2020, Vol 14, Issue 7, p1149
- ISSN
0975-7619
- Publication type
Article