We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cognitive Effects of Subthalamic Nucleus Stimulation in Parkinson's Disease: A Controlled Study.
- Authors
Sáez-Zea, Carmen; Escamilla-Sevilla, Francisco; Katati, Majed J.; Mínguez-Castellanos, Adolfo
- Abstract
Background: Subthalamic nucleus deep brain stimulation (STN-DBS) improves motor function in selected patients with Parkinson's disease (PD) but can be associated with variable changes in cognitive functions. Methods: We studied 21 patients selected for STN-DBS and compared 6-month clinical and neuropsychological outcomes between those who underwent surgery (n = 9) and those who voluntarily refused it (n = 12). Results: Motor and quality of life outcomes were markedly superior in the STN-DBS group versus controls. A wide neuropsychological battery was administered, and the whole sample showed a statistically significant worsening in phonemic verbal fluency, time to perform the Trail Making Test part B, Digit Symbol score of WAIS-III and color-naming score of the Stroop Test. In comparison to controls, a trend to a slightly worse deterioration in phonemic verbal fluency was observed in the STN-DBS patients and was significantly correlated with reductions in the l-dopa-equivalent daily dose (r = 0.850, p = 0.007). Conclusion: Our study confirms the safety of STN-DBS from a cognitive standpoint; a reduction in verbal fluency at 6 months after surgery can also be related to PD progression and medication reduction. Copyright © 2012 S. Karger AG, Basel
- Subjects
PARKINSON'S disease; BRAIN stimulation; COGNITION; BRAIN diseases; SURGERY
- Publication
European Neurology, 2012, Vol 68, Issue 6, p361
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000341380