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- Title
Impact of malnutrition diagnosed using Global Leadership Initiative on Malnutrition criteria on clinical outcomes of patients with gastric cancer.
- Authors
Xu, Li‐Bin; Shi, Ming‐Ming; Huang, Ze‐Xin; Zhang, Wei‐Teng; Zhang, Hui‐Hui; Shen, Xian; Chen, Xiao‐Dong; Xu, Li-Bin; Shi, Ming-Ming; Huang, Ze-Xin; Zhang, Wei-Teng; Zhang, Hui-Hui; Chen, Xiao-Dong
- Abstract
<bold>Objective: </bold>Our objective is to validate the effectiveness of the Global Leadership Initiative on Malnutrition (GLIM) criteria in malnutrition diagnosis compared with Patient-Generated Subjective Global Assessment (PG-SGA) and assess the impact of malnutrition diagnosed using GLIM criteria on the clinical outcomes of patients with GC.<bold>Methods: </bold>We retrospectively analyzed the data of 895 patients who underwent radical gastrectomy at the First Affiliated Hospital of Wenzhou Medical University. Nutrition assessment was performed on all patients according to the GLIM criteria and PG-SGA. The κ statistic was used to evaluate the agreement between two methods. Multivariate logistic regression and Cox regression based on single-factor analysis were used to predict postoperative complications and overall survival rates.<bold>Results: </bold>Based on the GLIM criteria, 38.3% of the patients were diagnosed as malnourished, including 21.7% Stage I (moderate malnutrition) and 16.6% Stage II (severe malnutrition). GLIM criteria had a moderate agreement with PG-SGA (κ = 0.548). Patients in the Stage II malnutrition group had a higher incidence of complications, a longer postoperative length of stay, and higher hospitalization costs. Logistic regression showed that Stage II malnutrition was an independent risk predictor of postoperative complications (odds ratio, 3.28; 95% confidence interval [CI], 2.18-4.94). Furthermore, Cox regression analysis showed that both Stage I (hazard ratio [HR], 1.52; 95% CI, 1.11-2.07; P = .009) and Stage II (HR, 1.85; 95% CI, 1.34-2.53; P < .001) malnutrition were independent risk predictors of overall survival.<bold>Conclusion: </bold>Diagnosis of malnutrition according to the GLIM criteria is useful in predicting the adverse postoperative clinical outcomes of patients with gastric cancer.
- Subjects
CHINA; SURGICAL complication risk factors; MALNUTRITION diagnosis; STOMACH tumors; LENGTH of stay in hospitals; ACADEMIC medical centers; NUTRITIONAL assessment; CONFIDENCE intervals; MULTIVARIATE analysis; RETROSPECTIVE studies; MEDICAL care costs; CANCER patients; RISK assessment; TREATMENT effectiveness; GASTRECTOMY; MALNUTRITION; FACTOR analysis; HOSPITAL care; LOGISTIC regression analysis; ODDS ratio; PROPORTIONAL hazards models; DISEASE complications
- Publication
JPEN Journal of Parenteral & Enteral Nutrition, 2022, Vol 46, Issue 2, p385
- ISSN
0148-6071
- Publication type
journal article
- DOI
10.1002/jpen.2127