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- Title
Monocyte and macrophage immunometabolism in atherosclerosis.
- Authors
Groh, Laszlo; Keating, Samuel T.; Joosten, Leo A. B.; Netea, Mihai G.; Riksen, Niels P.
- Abstract
Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in the development of lipid dense plaques. Chronic inflammation induced by Western-type diet is associated with the risk of developing atherosclerosis, and new insights shed light on the importance of metabolic and functional reprogramming in monocytes and macrophages for progression of atherosclerosis. This review aims to provide an overview of our current understanding into how the metabolic reprogramming of glucose, cholesterol, fatty acid, and amino acid metabolism in macrophages contributes to inflammation during atherosclerosis. Recent insights suggest that transcriptional and epigenetic adaptation within innate immune cells (termed <italic>trained immunity</italic>) play an important role in the pathogenesis of atherosclerosis. We propose that metabolic changes induced by pro-atherogenic lipoproteins partly mediate these changes in trained macrophages. Finally, we discuss the possibility of manipulating cellular metabolism of immune cells for targeted therapeutic intervention against atherosclerosis.
- Subjects
ATHEROSCLEROSIS; MONOCYTES; MACROPHAGES; DISEASE progression; CELL metabolism
- Publication
Seminars in Immunopathology, 2018, Vol 40, Issue 2, p203
- ISSN
1863-2297
- Publication type
Article
- DOI
10.1007/s00281-017-0656-7