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- Title
Perceptual distortions and delusional thinking following ketamine administration are related to increased pharmacological MRI signal changes in the parietal lobe.
- Authors
Stone, James; Kotoula, Vasileia; Dietrich, Craige; De Simoni, Sara; Krystal, John H.; Mehta, Mitul A.
- Abstract
Ketamine produces effects in healthy humans that resemble the positive, negative and cognitive symptoms of schizophrenia. We investigated the effect of ketamine administration on brain activity as indexed by blood-oxygen-level-dependent (BOLD) signal change response, and its relationship to ketamine-induced subjective changes, including perceptual distortion. Thirteen healthy participants volunteered for the study. All underwent a 15-min functional MRI acquisition with a ketamine infusion commencing after 5 min (approx 0.26 mg/kg over 20s followed by an infusion of approx. 0.42 mg/kg/h). Following the scan, participants self-rated ketamine-induced effects using the Psychotomimetic States Inventory. Ketamine led to widespread cortical and subcortical increases in BOLD response (FWE-corrected p < 0.01). Self-rated perceptual distortions and delusional thoughts correlated with increased BOLD response in the paracentral lobule (FWE-corrected p < 0.01). The findings suggest that BOLD increases in parietal cortices reflect ketamine effects on circuits that contribute to its capacity to produce perceptual alterations and delusional interpretations.
- Subjects
PERCEPTUAL disorders; DELUSIONS; MAGNETIC resonance imaging of the brain; KETAMINE; DRUG administration; PARIETAL lobe; PSYCHOPHARMACOLOGY; INTRAVENOUS anesthetics; MAGNETIC resonance imaging; OXYGEN; RESEARCH funding; SCHIZOPHRENIA; SUBSTANCE-induced psychoses
- Publication
Journal of Psychopharmacology, 2015, Vol 29, Issue 9, p1025
- ISSN
0269-8811
- Publication type
journal article
- DOI
10.1177/0269881115592337