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- Title
Clinical presentation and outcomes for adult ependymoma patients.
- Authors
Acquaye, Alvina A.; Vera, Elizabeth; Gilbert, Mark R.; Armstrong, Terri S.
- Abstract
<bold>Background: </bold>Outcomes projects can be a catalyst for determining disease- and treatment-related consequences for patients with rare tumors. The Adult Ependymoma Outcomes (AEO) survey uses self-reported experience to evaluate how this tumor affects patient groups throughout the illness trajectory.<bold>Methods: </bold>Patients completed the AEO survey via a Web-based portal. The survey included questions on treatment, tumor recurrence, and current health status; the MD Anderson Symptom Inventory Brain Tumor and Spine Tumor modules; and the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36).<bold>Results: </bold>The sample included 264 participants (57% female) with a median age of 46 years (range, 18-77 years). Radiation treatment was commonly used for patients who had brain involvement (χ2 (1) = 20.7; P < .001), underwent a partial resection (43%; χ2 (3) = 15.4; P < .001), or had a grade 3 tumor (41%; χ2 (2) = 18.8; P < .001). Recurrence occurred in a small group (29%), with grade 1 tumor patients 2.6 times more likely and grade 3 tumor patients 2.5 times more likely to experience recurrence than those with grade 2 tumors. Spine tumor patients had a higher symptom burden (mean, 2.8; scale, 0-10) than brain tumor patients (t(247) = -4.0), and they reported more moderate to severe symptoms (rating ≥ 5; 29%) than their counterparts (18%). Within the physical health portion of the SF-36, spine tumor patients reported worse health with respect to bodily pain (t(249) = 6.8; P < .001), physical functioning (t(252) = 4.1; P < .001), and vitality (t(202.2) = 3.0; P < .003).<bold>Conclusions: </bold>These results demonstrate the feasibility of implementing outcomes projects that report on the clinical and demographic characteristics of a rare patient population, and they underscore the importance of outcomes data in understanding disease-related issues. Cancer 2017;123:494-501. © 2016 American Cancer Society.
- Subjects
CANCER treatment; CENTRAL nervous system; EPENDYMOMA; QUALITY of life; SYMPTOMS; TUMORS; SURVEYS; BRAIN tumor treatment; GLIOMA treatment; BRAIN tumors; CANCER relapse; GLIOMAS; HEALTH status indicators; HEALTH surveys; HEALTH outcome assessment; QUESTIONNAIRES; SPINAL cord tumors; TUMOR treatment
- Publication
Cancer (0008543X), 2017, Vol 123, Issue 3, p494
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/cncr.30355