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- Title
Long-term soy consumption and tumor tissue MicroRNA and gene expression in triple-negative breast cancer.
- Authors
Guo, Xingyi; Cai, Qiuyin; Bao, Pingping; Wu, Jie; Wen, Wanqing; Ye, Fei; Zheng, Wei; Zheng, Ying; Shu, Xiao‐Ou
- Abstract
<bold>Background: </bold>Soy food intake may have protective effects against the risk for breast cancer, including estrogen receptor (ER)-negative breast cancer. However, the underlying molecular mechanisms remain unclear.<bold>Methods: </bold>To evaluate the association of soy intake with the expression of microRNAs (miRNAs) and genes in the tumor tissue of patients with triple-negative breast cancer (TNBC; ie, breast cancer lacking expression of ER, progesterone receptor, and human epidermal growth factor receptor 2), the expression of 800 miRNAs and 302 genes were measured with NanoString nCounter assays in formalin-fixed, paraffin-embedded tumor tissue from 272 TNBC patients. Soy intake during the 1-year period before the cancer diagnosis was assessed with a validated food-frequency questionnaire. The association of soy intake with the expression of miRNAs and genes was evaluated via linear regression analysis with adjustments for patient age and TNM stage.<bold>Results: </bold>A total of 14 miRNAs and 24 genes were significantly associated with soy food intake (P < .05): Thirteen of the 14 miRNAs (92.9%) and 9 of the 24 genes (37.5%), including tumor suppressors miR-29a-3p and IGF1R, showed overexpression for those women with high soy intake, whereas the remaining miRNAs and genes, including oncogenes KRAS and FGFR4, showed underexpression. Furthermore, cell growth-related genes showed a predominantly underexpression pattern according to a comparison of tumor samples from women with high soy food intake and samples from women with lower soy food intake.<bold>Conclusions: </bold>This study suggests that long-term prediagnosis soy intake may lead to increased expression of tumor suppressors and decreased expression of oncogenes, especially cell growth-related genes, in breast tumor tissues. Cancer 2016;122:2544-51. © 2016 American Cancer Society.
- Subjects
BREAST cancer treatment; SOYFOODS; MICRORNA; GENE expression; ESTROGEN receptors; BREAST tumor diagnosis; BREAST tumors; CELL lines; CLUSTER analysis (Statistics); FOOD habits; GENES; MOLECULAR structure; PUBLIC health surveillance; QUESTIONNAIRES; RESEARCH funding; RNA; TUMOR classification; BIOINFORMATICS; GENE expression profiling; TUMOR grading
- Publication
Cancer (0008543X), 2016, Vol 122, Issue 16, p2544
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/cncr.29981