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- Title
Enhancement of the Effects of Exfoliated Carbon Nanofibers by Bone Morphogenetic Protein in a Rat Femoral Fracture Model.
- Authors
Miyazaki, Masashi; Toyoda, Masahiro; Yoshiiwa, Toyomi; Kawano, Masanori; Kaku, Nobuhiro; Tsumura, Hiroshi
- Abstract
ABSTRACT Exfoliated carbon nanofibers (ExCNFs) are expected to serve as excellent scaffolds for promoting and guiding bone-tissue regeneration. We aimed to enhance the effects of ExCNFs with bone morphogenetic proteins (BMPs) and examine their feasibility and safety in clinical applications using a rat femoral fracture model. Group I ( n = 16) animals were implanted with control MedGEL. Group II ( n = 17) animals were implanted with MedGEL containing ExCNFs. Group III ( n = 15) animals were implanted with MedGEL containing 1 μg rhBMP-2. Group IV ( n = 15) animals were implanted with MedGEL containing 1 μg rhBMP-2 and ExCNFs. The rats were euthanized after 6 weeks, and their fractured femurs were explanted and assessed by manual palpation, radiographs, and high-resolution microcomputerized tomography (micro-CT); the femurs were also subjected to biomechanical and histological analysis. The fusion rates in Group IV (73.3%) were considerably higher than those in Groups I (25.0%), II (52.9%), and III (46.7%). The results demonstrated the enhancement of the bone repair effects of ExCNFs by BMP in a rat femoral fracture model. Our results suggest that the enhancement of the effects of ExCNFs by BMP makes the combination a possible attractive therapy for various orthopedic surgeries. © 2014 Orthopaedic Research Society. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:185-192, 2015.
- Subjects
FEMUR injuries; BONE morphogenetic proteins; CARBON nanofibers; CHEMICAL peel; LABORATORY rats; COMPUTED tomography; ORTHOPEDIC implants; THERAPEUTICS
- Publication
Journal of Orthopaedic Research, 2015, Vol 33, Issue 2, p185
- ISSN
0736-0266
- Publication type
Article
- DOI
10.1002/jor.22751