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- Title
High-resolution computed tomography in healthy smokers and never-smokers: a 6-year follow-up study of men born in 1933.
- Authors
Vikgren, J.; Boijsen, M.; Andelid, K.; A. Ekberg-Jansson; Larsson, S.; Bake, B.; Tylén, U.; Ekberg-Jansson, A; Tylén, U
- Abstract
<bold>Purpose: </bold>To elucidate whether emphysematous lesions and other high-resolution computed tomography (HRCT) findings considered associated with smoking are part of a progressive process, and to measure the extent to which similar changes are found in never-smokers.<bold>Material and Methods: </bold>Healthy smokers and never-smokers were recruited from a randomized epidemiological study and investigated with a 6-year interval. Emphysema, parenchymal and subpleural nodules, ground-glass opacities, bronchial alterations, and septal lines were evaluated in 66 subjects (40 smokers, 11 of whom had stopped smoking in the interval, and 26 never-smokers). Lung function was tested.<bold>Results: </bold>All except emphysematous lesions were present to some extent in never-smokers. Emphysema, parenchymal nodules, and septal lines occurred significantly more in current smokers, and a progression in extent of emphysema, ground-glass opacities, bronchial alterations and septal lines was seen. There was no significant change among those who stopped and never-smokers except for bronchial alterations, which progressed in never-smokers.<bold>Conclusion: </bold>In healthy, elderly never-smokers a low extent of various HRCT findings has to be considered normal. Emphysema, parenchymal nodules, and ground-glass opacities are indicative of smoking-induced disease. Further progress may cease if smoking is stopped.
- Subjects
TOMOGRAPHY; SMOKING; PHYSIOLOGICAL effects of tobacco; PULMONARY emphysema; LUNG diseases; HEALTH of older people; COMPUTED tomography; LONGITUDINAL method; TIME
- Publication
Acta Radiologica, 2004, Vol 45, Issue 1, p44
- ISSN
0284-1851
- Publication type
journal article
- DOI
10.1080/02841850310002970