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- Title
The cellular receptor to human rhinovirus 2 binds around the 5-fold axis and not in the canyon: a structural view.
- Authors
Hewart, Elizabeth A.; Neuman, Emmanuelle; Conway, James F.; Moser, Rosita; Ronacher, Bernhard; Marlovits, Thomas C.; Blaas, Dieter
- Abstract
Human rhinovirus serotype 2 (HRV2) belongs to the minor group of HRVs that bind to members of the LDL-receptor family including the very low density lipoprotein (VLDL)-receptor (VLDL-R). We have determined the structures of the complex between HRV2 and soluble fragments of the VLDL-R to 15 Å resolution by cryo-electron microscopy. The receptor fragments, which include the first three ligand-binding repeats of the VLDL-R (V1-3), bind to the small star-shaped dome on the icosahedral 5-fold axis. This is in sharp contrast to the major group of HRVs where the receptor site for ICAM-1 is located at the base of a depression around each 5-fold axis. Homology models of the three domains of V1-3 were used to explore the virus-receptor interaction. The footprint of VLDL-R on the viral surface covers the BC- and HI-loops on VPL
- Subjects
RHINOVIRUSES; LIPOPROTEINS; ELECTRON microscopy; LIGANDS (Biochemistry); HOMOLOGY (Biology)
- Publication
EMBO Journal, 2000, Vol 19, Issue 23, p6317
- ISSN
0261-4189
- Publication type
Article
- DOI
10.1093/emboj/19.23.6317