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- Title
Gender-Specific Associations of Serum Insulin-Like Growth Factor-1 With Bone Health and Fractures in Older Persons.
- Authors
van Varsseveld, N C; Sohl, E; Drent, M L; Lips, P
- Abstract
<bold>Context: </bold>IGF-1 plays a role in bone metabolism. Although IGF-1 and bone mass both decrease with advancing age, their relationship in older individuals remains to be elucidated.<bold>Objective: </bold>The objective was to investigate associations of serum IGF-1 cross-sectionally with quantitative ultrasound and bone mineral density (BMD), and longitudinally with 3-year change in BMD and 10-year fracture risk in older individuals.<bold>Design, Setting, and Patients: </bold>The study included 627 men and 656 women aged ≥ 65 years from the Longitudinal Aging Study Amsterdam, an ongoing, population-based cohort study.<bold>Main Outcome Measures: </bold>Main outcome measures included baseline serum IGF-1 concentration; baseline quantitative ultrasound of the heel, including broadband ultrasound attenuation and speed of sound; BMD measured at several body sites at baseline and after 3 years; and prospective fracture incidence over 10 years. Associations were adjusted for relevant confounders.<bold>Results: </bold>Women, but not men, in the lowest quintile of IGF-1 concentration had lower broadband ultrasound attenuation (B = -4.53; P = .03) and a greater 3-year decrease in total hip BMD (B = -0.02; P = .05), than women in the highest quintile of IGF-1. Moreover, compared to women in the highest quintile of IGF-1, women in the combined lowest four quintiles of IGF-1 had an increased 10-year fracture risk (hazard ratio = 1.98; P = .05).<bold>Conclusions: </bold>Associations of lower IGF-1 with lower BUA, greater 3-year decrease in BMD, and increased 10-year fracture risk were only observed in women, not in men. These results support previous findings of gender differences in the relationship between IGF-1 and bone in older individuals.
- Subjects
NETHERLANDS; BONE physiology; AGING; BONES; BONE fractures; HUMAN reproduction; LONGITUDINAL method; MOTOR ability; OSTEOPOROSIS; RISK assessment; SOMATOMEDIN; BONE density; DISEASE incidence; CROSS-sectional method
- Publication
Journal of Clinical Endocrinology & Metabolism, 2015, Vol 100, Issue 11, p4272
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2015-2549