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- Title
A very complicated UTI: malakoplakia following E. coli urinary tract infection.
- Authors
Fatola, Ayotola; Johnson, Benjamin C.; Walsh, Laura; Fang, Diana; White, Marissa J.; Le, Dustin; Atta, Mohamed G.; Sperati, C. John; Hager, David N.
- Abstract
Malakoplakia is a rare inflammatory disorder believed to result from a defect in macrophage phagocytic function triggering a granulomatous reaction. It can present with genitourinary, gastrointestinal, or cutaneous manifestations in immunocompromised or, less commonly, immunocompetent hosts. We describe a case of renal malakoplakia in a young, otherwise healthy patient presenting with nephromegaly and sepsis following an E. coli urinary tract infection. We discuss diagnosis and management, including antibiotic selection and the decision to pursue nephrectomy. This case highlights the potential for kidney recovery with prolonged antibiotic therapy in conjunction with adjunct immunomodulatory therapies and source control.
- Subjects
ESCHERICHIA coli; URINARY tract infections; CUTANEOUS manifestations of general diseases
- Publication
BMC Nephrology, 2024, Vol 25, Issue 1, p1
- ISSN
1471-2369
- Publication type
Article
- DOI
10.1186/s12882-024-03640-9