We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Analysis of the interventions in antineoplastic therapy by a clinical pharmacy service at a tertiary hospital in Brazil.
- Authors
da Rocha, Camile; Carlotto, Juliane; Zanis Neto, Jose
- Abstract
Background: Medication errors are avoidable occurrences that can assume clinically significant dimensions and impose relevant costs to the health system, especially in the context of antineoplastic therapy. Objective: Assess the clinical significance and economic impacts of a clinical pharmaceutical service. This retrospective study consists of an analysis of pharmacy interventions and drug-related problems found in a review of electronic prescriptions referring to antineoplastic therapy of a public teaching tertiary hospital in Brazil. Method: Retrospective descriptive study obtained from electronic records of drug-related problems and pharmaceutical interventions related to antineoplastic therapy for oncological and hematological diseases, obtained through the pharmacotherapy review service. The accepted interventions were analyzed for the financial impact generated, evaluating your direct costs. The perception of clinical significance of a random sample of interventions was ascertained by the experts' opinion, using the Delphi method. Results: The most frequent problem was a "lack of information to professionals" (25.06%), "problems as to the frequency and interval of doses" (22.90%), and "medication underdosing" (16.20%). Dose adjustment (31.50%) and clarifications (30.90%) were the most frequent pharmaceutical interventions. In the second round of Delphi, experts rated 77.77% of interventions as extremely significant and very significant. The main drugs reported in the interventions were cyclophosphamide, carboplatin, methotrexate, folinic acid, and monoclonal antibodies. The savings amounted to US$1,193,970.18 and involved mainly bortezomib, dactinomycin, and monoclonal antibodies. Conclusion: Clinical pharmacy services contributed to the rational use of medicines presenting clinical significance and avoiding waste of financial resources.
- Subjects
BRAZIL; THERAPEUTIC use of monoclonal antibodies; THERAPEUTIC use of antineoplastic agents; FOLINIC acid; ACADEMIC medical centers; CARBOPLATIN; RESEARCH methodology; MEDICAL care costs; TERTIARY care; RETROSPECTIVE studies; ANTINEOPLASTIC agents; HOSPITAL pharmacies; METHOTREXATE; ECONOMICS; DESCRIPTIVE statistics; CYCLOPHOSPHAMIDE; PHARMACEUTICAL industry; CANCER patient medical care; DELPHI method
- Publication
Journal of Oncology Pharmacy Practice, 2022, Vol 28, Issue 5, p1049
- ISSN
1078-1552
- Publication type
Article
- DOI
10.1177/10781552211017650