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- Title
"Turn‐On" Activatable AIE Dots for Tumor Hypoxia Imaging.
- Authors
Xue, Tianhao; Jia, Xiangqian; Wang, Jilei; Xiang, Jingyuan; Wang, Wei; Du, Juanjuan; He, Yaning
- Abstract
A hypoxia‐responsive fluorescence probe of amphiphilic PEGylated azobenzene caged tetraphenylethene (TPE) for tumor cell imaging is reported; it possesses excellent solubility in aqueous medium due to the easy formation of micelles by self‐assembly. The fluorescence resonance energy transfer (FRET) process ensures that the fluorescence of the azobenene caged AIE fluorogen is quenched efficiently. When cultured with tumor cells, the azo‐bond is reduced under hypoxia conditions and the fluorescence of AIE fluorogen recovers dramatically. Besides using UV light, NIR light can also be used as the excited light resource to generate the fluorescence due to the two‐photon fluorescence imaging process.
- Subjects
FLUORESCENCE resonance energy transfer; CELL imaging; HYPOXEMIA
- Publication
Chemistry - A European Journal, 2019, Vol 25, Issue 41, p9634
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201902296