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- Title
A Ratiometric Fluorescent Probe for K<sup>+</sup> in Water Based on a Phenylaza‐18‐Crown‐6 Lariat Ether.
- Authors
Schwarze, Thomas; Riemer, Janine; Holdt, Hans‐Jürgen
- Abstract
Abstract: This work presents two molecular fluorescent probes 1 and 2 for the selective determination of physiologically relevant K+ levels in water based on a highly K+/Na+ selective building block, the o‐(2‐methoxyethoxy)phenylaza‐18‐crown‐6 lariat ether unit. Fluorescent probe 1 showed a high K+‐induced fluorescence enhancement (FE) by a factor of 7.7 of the anthracenic emission and a dissociation constant (Kd) value of 38 m m in water. Further, for 2+K+, we observed a dual emission behavior at 405 and 505 nm. K+ increases the fluorescence intensity of 2 at 405 nm by a factor of approximately 4.6 and K+ decreases the fluorescence intensity at 505 nm by a factor of about 4.8. Fluorescent probe 2+K+ exhibited a Kd value of approximately 8 m m in Na+‐free solutions and in combined K+/Na+ solution a similar Kd value of about 9 m m was found, reflecting the high K+/Na+ selectivity of 2 in water. Therefore, 2 is a promising fluorescent tool to measure ratiometrically and selectively physiologically relevant K+ levels.
- Subjects
FLUORESCENT probes; POTASSIUM ions; CROWN ethers; ANTHRACENE; SOLUTION (Chemistry)
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 40, p10116
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201802306