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- Title
Enantioselective Formal C−H Conjugate Addition of Acetanilides to β-Substituted Acrylates by Chiral Iridium Catalysts.
- Authors
Shibata, Takanori; Michino, Masamichi; Kurita, Hisaki; Tahara, Yu‐ki; Kanyiva, Kyalo Stephen
- Abstract
The Ir-catalyzed enantioselective reaction of substituted acetanilides with β-substituted α,β-unsaturated esters provided chiral 3,3-disubstituted propanoates in high yield with good-to-excellent enantiomeric excess (up to 99 % ee). This transformation, initiated by sp2 C−H bond activation, is the first example of enantioselective formal C−H conjugate addition to β-substituted α,β-unsaturated carbonyl compounds. The starting materials are commercially available and/or readily accessible.
- Subjects
IRIDIUM catalysts; ENANTIOSELECTIVE catalysis; ACETANILIDES; ACRYLATES; CHEMICAL yield; CARBON-hydrogen bonds
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 1, p88
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201604962